STIMULATION OF LOW-DENSITY-LIPOPROTEIN RECEPTOR ACTIVITY IN LIVER MEMBRANE OF GUGGULSTERONE TREATED RATS

被引：44

作者：

SINGH, V ^{[1
]}

KAUL, S ^{[1
]}

CHANDER, R ^{[1
]}

KAPOOR, NK ^{[1
]}

机构：

[1] CENT DRUG RES INST,DIV BIOCHEM,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

PHARMACOLOGICAL RESEARCH | 1990年 / 22卷 / 01期

关键词：

guggulsterone; hypolipidaemic activity; liver membrane lipids; low density lipoprotein binding;

D O I：

10.1016/1043-6618(90)90741-U

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chronic feeding of guggulsterone to rats showed hypolipidaemic activity in blood serum and liver membrane lipids. The decrease in serum cholesterol is associated with enhanced uptake of LDL by the liver through receptor mediated endocytosis, located on the surface of the cell membrane. In the present communication it has been shown that membranes prepared from liver of guggulsterone treated rats exhibit up to 87% increase in binding sites for human125I-LDL Significant decrease in lipid levels of serum as well as of membrane were observed. Lipid lowering activity of the drug in relation to LDL catabolism and other possible mechanisms have been explained. © 1990 The Italian Pharmacological Society.

引用

页码：37 / 44

页数：8

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