NEUROIMMUNOHISTOCHEMICAL ANALYSIS OF PERIDISCAL NOCICEPTIVE NEURAL ELEMENTS

被引：77

作者：

KONTTINEN, YT

GRONBLAD, M

ANTTIPOIKA, I

SEITSALO, S

SANTAVIRTA, S

HUKKANEN, M

POLAK, JM

机构：

[1] Fourth Department of Medicine, University Central Hospital, Helsinki

[2] Department of Physical Medicine and Rehabilitation, University Central Hospital, Helsinki

[3] Orthopaedic Hospital of the Invalid Foundation, Helsinki

[4] Jorvi Hospital, Espoo

[5] Hammersmith Hospital, Royal Postgraduate Medical School

来源：

SPINE | 1990年 / 15卷 / 05期

关键词：

Calcitonin gene-related peptide; Disc degeneration; Disc pain; Immunohistology; Low-back pain; Neurofilaments; Neuropeptides; Substance P;

D O I：

10.1097/00007632-199005000-00008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Twenty-three perioperative tissue samples from lumbar disc operations on 11 patients were studied immunohis-tochemically using the sensitive avidin-biotin-per- oxidase complex (ABC) method and specific heterologous antisera for the presence of neurofilament-positive neural elements containing nociceptive neuropeptides substance P (SP) and/or calcitonin gene-related peptidè (CGRP). Histologically, neural elements were especially abundant in the posterior longitudinal ligament, there being also a few demonstrable nerves in the peripheral anulus fibrosus. These nerves often showed a co-localization of cytoskeletal neurofilaments together with SP and/or CGRP immunoreactivity. It is suggested that pressure and chemical irritation of nociceptive nerves dependent on degenerated discs excite sensory neural ele-ments, especially in the posterior longitudinal ligament and possibly also in the peripheral parts of the.anulus fibrosus, while the disc itself, at least if not penetrated by vascular granular tissue, is painless and neuroanatomi- cally lacks a structural basis for pain perception. © Lippincott-Raven Publishers.

引用

页码：383 / 386

页数：4

共 21 条

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