INDUCTION OF DIFFERENTIATION OF THE HUMAN PROMYELOCYTIC CELL-LINE HL-60 BY ACTIVIN EDF

被引：22

作者：

YAMADA, R

SUZUKI, T

HASHIMOTO, M

ETO, Y

SHIOKAWA, K

MURAMATSU, M

机构：

[1] UNIV TOKYO,FAC SCI,INST ZOOL,DEPT MOLEC EMBRYOL,TOKYO 113,JAPAN

[2] AJINOMOTO CO INC,CENT RES LABS,KAWASAKI KU,KAWASAKI,KANAGAWA 210,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 187卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)81461-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A human promyelocytic cell line, HL-60, treated with activin/EDF was found to differentiate into monocyte/macrophage-like cells. This was shown not only by morphology but by the loss of myeloperoxidase granules and the appearance of non-specific esterase. Dose-dependent inhibition of the differentiation by follistatin, an activin-binding protein, confirmed that it was indeed caused by activin. Thus, activin/EDF exerts its effect on hematopoietic cells not only on erythroid differentiation but also on at least a part of myeloid cell differentiation. © 1992 Academic Press, Inc.

引用

页码：79 / 85

页数：7

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