THE TREATMENT OF ADVANCED MERKEL CELL-CARCINOMA - A MULTIMODALITY CHEMOTHERAPY AND RADIATION-THERAPY TREATMENT APPROACH

被引:37
作者
FENIG, E [1 ]
LURIE, H [1 ]
KLEIN, B [1 ]
SULKES, A [1 ]
机构
[1] TEL AVIV UNIV,SACKLER SCH MED,TEL AVIV,ISRAEL
来源
JOURNAL OF DERMATOLOGIC SURGERY AND ONCOLOGY | 1993年 / 19卷 / 09期
关键词
D O I
10.1111/j.1524-4725.1993.tb01019.x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND. The optimal management of Merkel cell carcinoma has not been clearly defined. OBJECTIVE. To describe the treatment of eight patients who presented with Merkel cell carcinoma. METHODS. Eight patients with advanced locoregional Merkel cell carcinoma were seen in our institute over a 7-year period. Four patients were successfully treated by induction chemotherapy after excisional biopsy, followed by radiotherapy. Three patients died from widespread metastases and one from neutropenic sepsis induced by chemotherapy. RESULTS. These cases demonstrate the potential lethality and aggressive nature of this rare skin tumor despite its chemosensitive and radioresponsive character. In all four patients who are alive and disease-free, chemotherapy was given first and radiotherapy was given as consolidation. CONCLUSION. We suggest that a multimodality treatment approach-chemotherapy followed by radiotherapy-is indicated in patients with advanced Merkel cell carcinoma.
引用
收藏
页码:860 / 864
页数:5
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