INHIBITION OF ETHOXYRESORUFIN DEETHYLASE ACTIVITY BY NATURAL FLAVONOIDS IN HUMAN AND RAT-LIVER MICROSOMES

被引：12

作者：

SIESS, MH

LEBON, AM

SUSCHETET, M

RAT, P

机构：

[1] Station de Recherches sur la Qualite des Aliments de 1’Homme, INRA, Dijon Cedex, 21034

[2] Universite de Bourgogne, Centre Hospitalier Regional, Service de Chirurgie Viscerale, Dijon Cedex

来源：

FOOD ADDITIVES AND CONTAMINANTS | 1990年 / 7卷

关键词：

Ethoxyresorufin deethylase; Flavones; Flavonols; Man; Rat;

D O I：

10.1080/02652039009373876

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Several flavones and flavonols (chrysin, quercetin, luteolin, flavone and 7, 8-benzoflavone) were found to inhibit ethoxyresorufin deethylase (EROD) activity in human and rat liver microsomes. In man, molecules without hydroxyl groups are more powerful inhibitors than polyhydroxylated flavonoids (7, 8-benzoflavone > flavone > chrysin > luteolin > quercetin > morin). In rat, chrysin was the strongest inhibitor and the less effective were morin and 7, 8-benzoflavone. For all molecules human microsomes were more sensitive than rat microsomes. The most important difference concerned 7, 8-benzoflavone which was 10 000-fold more potent in man. © 1990 Taylor & Francis Ltd.

引用

页码：S178 / S181

页数：4

共 8 条

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