URIC-ACID AS AN INHIBITOR OF CYCLOPHOSPHAMIDE-INDUCED MICRONUCLEI IN MICE

被引：13

作者：

ALBEKAIRI, AM

QURESHI, S

CHAUDHRY, MA

SHAH, AH

机构：

[1] KING SAUD UNIV, COLL PHARM, CTR EXPTL ANIM CARE, QUAL CONTROL & RES LAB, RIYADH 11451, SAUDI ARABIA

[2] KING SAUD UNIV, COLL SCI, DEPT ZOOL, RIYADH, SAUDI ARABIA

[3] CENT LAB DRUG ANAL, MOH, RIYADH 11525, SAUDI ARABIA

来源：

MUTATION RESEARCH | 1991年 / 262卷 / 02期

关键词：

URIC ACID; MICRONUCLEUS INHIBITION; (MICE);

D O I：

10.1016/0165-7992(91)90116-L

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Swiss albino male mice, 6-8 weeks old, were treated orally with different doses of uric acid dissolved in water for 7 days. Some of the mice in each group were injected i.p. with cyclophosphamide (25 mg/kg) and killed after 30 h. The blood of all animals was analyzed for uric acid levels. The femoral cells of the mice in different groups were collected and studied. Uric acid was found to be devoid of mitodepressant or clastogenic activity at 10-100 mg/kg/day. Pretreatment with uric acid was found to provide significant protection against cyclophosphamide-induced bone marrow depression and micronucleated polychromatic erythrocytes.

引用

页码：115 / 118

页数：4

共 16 条

[1] URIC-ACID PROVIDES AN ANTIOXIDANT DEFENSE IN HUMANS AGAINST OXIDANT-CAUSED AND RADICAL-CAUSED AGING AND CANCER - A HYPOTHESIS [J].