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MK801 ANTAGONISM OF THE PROLONGED DEPLETION OF STRIATAL DOPAMINE BY AMPHETAMINE IN IPRINDOLE-TREATED RATS

被引：7
作者：
HEMRICKLUECKE, SK
HENDERSON, MG
FULLER, RW
机构：
[1] Eli Lilly and Company, Lilly Corporate Center, Indianapolis
来源：
LIFE SCIENCES | 1992年 / 50卷 / 06期
关键词：
D O I：
10.1016/0024-3205(92)90383-Z
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The administration of amphetamine to rats pretreated with iprindole to inhibit the metabolism of amphetamine results in a long-lasting depletion of striatal dopamine and its metabolites, DOPAC and HVA. Pretreatment with MK801, a noncompetitive antagonist of the NMDA (N-methyl-D-aspartate) subclass of excitatory amino acid receptors, antagonized the depletion of striatal dopamine, DOPAC and HVA 3 days after a single dose of amphetamine in iprindole-treated rats. MK801 pretreatment was effective up to 4 hours but not at 8 or 24 hours in preventing amphetamine effects on striatal dopamine, DOPAC and HVA.
引用
收藏
页码：PL31 / PL33
页数：3
相关论文
共 14 条
[1]  
BOWYER JF, 1991, J PHARMACOL EXP THER, V257, P262
[2]   METHAMPHETAMINE-INDUCED NEURONAL DAMAGE - A POSSIBLE ROLE FOR FREE-RADICALS [J].
DEVITO, MJ ;
WAGNER, GC .
NEUROPHARMACOLOGY, 1989, 28 (10) :1145-1150
[3]   LONG-LASTING DEPLETION OF STRIATAL DOPAMINE BY A SINGLE INJECTION OF AMPHETAMINE IN IPRINDOLE-TREATED RATS [J].
FULLER, RW ;
HEMRICKLUECKE, S .
SCIENCE, 1980, 209 (4453) :305-307
[4]  
FULLER RW, 1989, J PHARMACOL EXP THER, V248, P50
[5]   LONG-TERM EFFECTS OF MULTIPLE DOSES OF METHAMPHETAMINE ON NEOSTRIATAL TRYPTHOPHAN HYDROXYLASE, TYROSINE-HYDROXYLASE, CHOLINE-ACETYLTRANSFERASE AND GLUTAMATE-DECARBOXYLASE ACTIVITIES [J].
HOTCHKISS, AJ ;
MORGAN, ME ;
GIBB, JW .
LIFE SCIENCES, 1979, 25 (16) :1373-1378
[6]   LONG-TERM EFFECTS OF REPEATED METHYLAMPHETAMINE ADMINISTRATION ON DOPAMINE AND SEROTONIN NEURONS IN THE RAT-BRAIN - A REGIONAL STUDY [J].
RICAURTE, GA ;
SCHUSTER, CR ;
SEIDEN, LS .
BRAIN RESEARCH, 1980, 193 (01) :153-163
[7]  
SCHMIDT CJ, 1985, J PHARMACOL EXP THER, V233, P539
[8]  
SCHUSTER CR, 1983, FED PROC, V42, P1016
[9]   FORMATION OF 6-HYDROXYDOPAMINE IN CAUDATE-NUCLEUS OF THE RAT-BRAIN AFTER A SINGLE LARGE DOSE OF METHYLAMPHETAMINE [J].
SEIDEN, LS ;
VOSMER, G .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1984, 21 (01) :29-31
[10]  
SONSALLA PK, 1991, J PHARMACOL EXP THER, V256, P506
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