NASAL ABSORPTION OF LEUCINE ENKEPHALIN IN RATS AND THE EFFECTS OF AMINOPEPTIDASE INHIBITION, AS DETERMINED FROM THE PERCENTAGE OF THE DOSE UNABSORBED

被引：7

作者：

HUSSAIN, MA ^{[1
]}

AUNGST, BJ ^{[1
]}

机构：

[1] DUPONT MERCK PHARMACEUT CO,POB 80400,WILMINGTON,DE 19880

来源：

PHARMACEUTICAL RESEARCH | 1992年 / 9卷 / 10期

关键词：

NASAL; ABSORPTION; ENKEPHALIN; PEPTIDE; METABOLISM; INHIBITOR;

D O I：

10.1023/A:1015882006897

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：1362 / 1364

页数：3

共 9 条

[1]

AUNGST BJ, 1991, J PHARMACOL EXP THER, V259, P139

[2] ABSORPTION OF POLYETHYLENE GLYCOL-600 THROUGH POLYETHYLENE GLYCOL-2000 - THE MOLECULAR-WEIGHT DEPENDENCE OF GASTROINTESTINAL AND NASAL ABSORPTION [J].

DONOVAN, MD ;

FLYNN, GL ;

AMIDON, GL .

PHARMACEUTICAL RESEARCH, 1990, 7 (08) :863-868

[3] MECHANISM OF NASAL ABSORPTION OF DRUGS .3. NASAL ABSORPTION OF LEUCINE ENKEPHALIN [J].

FARAJ, JA ;

HUSSAIN, AA ;

ARAMAKI, Y ;

ISEKI, K ;

KAGOSHIMA, M ;

DITTERT, LW .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1990, 79 (08) :698-702

[4] HYDROLYSIS OF LEUCINE ENKEPHALIN IN THE NASAL CAVITY OF THE RAT - A POSSIBLE FACTOR IN THE LOW BIOAVAILABILITY OF NASALLY ADMINISTERED PEPTIDES [J].

HUSSAIN, A ;

FARAJ, J ;

ARAMAKI, Y ;

TRUELOVE, JE .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 133 (03) :923-928

[5] AN AMINOBORONIC ACID-DERIVATIVE INHIBITS THYMOPENTIN METABOLISM BY MUCOSAL MEMBRANE AMINOPEPTIDASES [J].

HUSSAIN, MA ;

KOVAL, CA ;

SHENVI, AB ;

AUNGST, BJ .

LIFE SCIENCES, 1990, 47 (03) :227-231

[6] THE USE OF ALPHA-AMINOBORONIC ACID-DERIVATIVES TO STABILIZE PEPTIDE DRUGS DURING THEIR INTRANASAL ABSORPTION [J].

HUSSAIN, MA ;

SHENVI, AB ;

ROWE, SM ;

SHEFTER, E .

PHARMACEUTICAL RESEARCH, 1989, 6 (02) :186-189

[7] PEPTIDASE ACTIVITIES IN ABSORPTIVE MUCOSAE [J].

LEE, VHL .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1989, 17 (05) :937-940

[8] INVITRO STUDY OF INTESTINAL-ABSORPTION AND METABOLISM OF 8-L-ARGININE VASOPRESSIN AND ITS ANALOGS [J].

MATUSZEWSKA, B ;

LIVERSIDGE, GG ;

RYAN, F ;

DENT, J ;

SMITH, PL .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1988, 46 (1-2) :111-120

[9] ALPHA-AMINOBORONIC ACID-DERIVATIVES - EFFECTIVE INHIBITORS OF AMINOPEPTIDASES [J].

SHENVI, AB .

BIOCHEMISTRY, 1986, 25 (06) :1286-1291

← 1 →