IMMUNOHISTOCHEMICAL EVALUATION OF EPIDERMIS OVERLYING BASAL-CELL CARCINOMAS

被引:18
作者
KIKUCHI, A [1 ]
SAKURAOKA, K [1 ]
SHIMIZU, H [1 ]
NISHIKAWA, T [1 ]
机构
[1] SAISEIKAI YOKOHAMASHI NANBU HOSP,DEPT DERMATOL,YOKOHAMA,JAPAN
关键词
D O I
10.1111/j.1365-2133.1993.tb00260.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
We have examined the character and carcinogenic properties of the normal-appearing epidermis overlying basal cell carcinomas by immunohistochemical methods, employing a series of monoclonal antibodies. The labelling index was significantly increased in the atrophic epidermis overlying basal cell carcinomas (solid type, n = 20), compared with the epidermis overlying or adjacent to squamous cell carcinoma (n = 20), keratoacanthoma (n = 10), dermatofibroma (n = 10), neurofibroma (n = 10), soft fibroma (n = 10). pyogenic granuloma (n = 10) and cutaneous leiomyoma (n = 5). Cells which expressed epidermal growth factor (EGF) receptor were detected in all layers of the epidermis over the basal cell carcinomas, but not the other tumours. Basement membrane-related antigens, including bullous pemphigoid antigen and GB3 antigen, were decreased in the epidermis. AE1, the monoclonal antibody against basal cell keratin, reacted with the uppermost layers of the normal-appearing epidermis overlying the basal cell carcinomas. ICAM-1 expression was very weak in the overlying epidermis. The dermis subjacent to the proliferating epidermis showed staining for transforming growth factor-alpha (TGF-alpha), strong positive PECAM-1 staining of endothelium, and numerous HLA-DR-positive cells. From these results, we suggest that the proliferative activity in the epidermis overlying basal cell carcinomas is not a state induced by the dermal infiltrate, but represents carcinogenic activity of the epidermis.
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页码:644 / 649
页数:6
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