IMMUNOENHANCING ACTIVITY OF NPT-15392 - A POTENTIAL IMMUNE-RESPONSE MODIFIER

NPT 15392, a new immunomodulating compound related to inosine in structure and isoprinosine in action, enhanced T-cell dependent immune responses. Antibody responses to sheep red blood cells were augmented 2 to 3-fold in mice receiving NPT 15392 while T-cell independent antibody responses to TNP-LPS [trinitrophenyl-lipopolysaccharide] were unaffected. NPT 15392 did not enhance or alter the number of clonable B cells. This drug also increased cytotoxic T-lymphocyte responses to allogeneic tumor cells but did not alter the number of cytotoxic precursor cells. Immature hematopoietic cell classes (clonable progenitor cells) were also monitored but were not influenced by NPT 15392.