REGIOSELECTIVE AND ENANTIOSPECIFIC SYNTHESIS OF 6-SUBSTITUTED AND 5,6-DISUBSTITUTED HEXAHYDROPYRIMIDINES

被引：9

作者：

GARRATT, PJ ^{[1
]}

THORN, SN ^{[1
]}

WRIGGLESWORTH, R ^{[1
]}

机构：

[1] SANDOZ INST MED RES,LONDON WC1E 6BN,ENGLAND

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(00)74861-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preference for 5- over 6-membered rings in the intramolecular cyclisation of amines with diesters can be partially overcome with mixed methyl (or benzyl), tert-butyl diesters, and this effect is enhanced where there is a beta-substituent. The hexahydropyrimidines are formed enatiospecifically, the amount of racemization usually being less with a beta-substituent present.

引用

页码：691 / 694

页数：4

共 6 条

[1] NON-PROTEINOGENIC AMINO-ACID SYNTHESIS - SYNTHESIS OF BETA, GAMMA-UNSATURATED ALPHA-AMINO-ACIDS FROM ASPARTIC-ACID [J].