BLOOD SCREENING FOR NON-A, NON-B HEPATITIS BY HEPATITIS-C VIRUS-ANTIBODY ASSAY

被引:34
作者
KATAYAMA, T
KIKUCHI, S
TANAKA, Y
SAITO, I
MIYAMURA, T
CHOO, QL
HOUGHTON, M
KUO, G
机构
[1] NATL INST HLTH,DEPT ENTEROVIRUSES,2-10-35 KAMIOSAKI,SHINAGAWA KU,TOKYO 141,JAPAN
[2] TOKYO NATL CHEST HOSP,DEPT SURG,KIYOSE,TOKYO 204,JAPAN
[3] CHIRON CORP,EMERYVILLE,CA 94608
关键词
D O I
10.1046/j.1537-2995.1990.30490273448.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
ABSTRACT: Hepatitis C virus (HCV) antibody was detected in 1499 donor sera by radioimmunoassay using an antigen expressed in yeast from a cDNA clone of the HCV genome. Eighteen samples over 4200 counts per minute (cpm) were considered to contain infectious HCV because these recipients developed typical posttransfusion non‐A,non‐B hepatitis after transfusion. The antibody‐positive sera were all within the normal range of ALT levels. This assay system is thus useful for the screening for blood transfusion. 1990 AABB
引用
收藏
页码:374 / 376
页数:3
相关论文
共 6 条
  • [1] DETECTION OF ANTIBODY TO HEPATITIS-C VIRUS IN PROSPECTIVELY FOLLOWED TRANSFUSION RECIPIENTS WITH ACUTE AND CHRONIC NON-A-HEPATITIS, NON-B-HEPATITIS
    ALTER, HJ
    PURCELL, RH
    SHIH, JW
    MELPOLDER, JC
    HOUGHTON, M
    CHOO, QL
    KUO, G
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (22) : 1494 - 1500
  • [2] ISOLATION OF A CDNA CLONE DERIVED FROM A BLOOD-BORNE NON-A, NON-B VIRAL-HEPATITIS GENOME
    CHOO, QL
    KUO, G
    WEINER, AJ
    OVERBY, LR
    BRADLEY, DW
    HOUGHTON, M
    [J]. SCIENCE, 1989, 244 (4902) : 359 - 362
  • [3] HUMAN CU/ZN SUPEROXIDE-DISMUTASE CDNA - ISOLATION OF CLONES SYNTHESIZING HIGH-LEVELS OF ACTIVE OR INACTIVE ENZYME FROM AN EXPRESSION LIBRARY
    HALLEWELL, RA
    MASIARZ, FR
    NAJARIAN, RC
    PUMA, JP
    QUIROGA, MR
    RANDOLPH, A
    SANCHEZPESCADOR, R
    SCANDELLA, CJ
    SMITH, B
    STEIMER, KS
    MULLENBACH, GT
    [J]. NUCLEIC ACIDS RESEARCH, 1985, 13 (06) : 2017 - 2034
  • [4] AN ASSAY FOR CIRCULATING ANTIBODIES TO A MAJOR ETIOLOGIC VIRUS OF HUMAN NON-A, NON-B-HEPATITIS
    KUO, G
    CHOO, QL
    ALTER, HJ
    GITNICK, GL
    REDEKER, AG
    PURCELL, RH
    MIYAMURA, T
    DIENSTAG, JL
    ALTER, MJ
    STEVENS, CE
    TEGTMEIER, GE
    BONINO, F
    COLOMBO, M
    LEE, WS
    KUO, C
    BERGER, K
    SHUSTER, JR
    OVERBY, LR
    BRADLEY, DW
    HOUGHTON, M
    [J]. SCIENCE, 1989, 244 (4902) : 362 - 364
  • [5] MIYAMURA T, IN PRESS P NATL ACAD
  • [6] WROBLEWSKI F, 1956, P SOC EXP BIOL MED, V91, P569