INVITRO TRANSFORMATION OF DITHIOPYR BY RAT-LIVER ENZYMES - CONVERSION OF METHYLTHIOESTERS TO ACIDS BY OXYGENASES

被引：14

作者：

FENG, PCC

SOLSTEN, RT

机构：

[1] Monsanto Agricultural Co., A Unit of Monsanto Co., St Louis MO 63198

来源：

XENOBIOTICA | 1991年 / 21卷 / 10期

关键词：

D O I：

10.3109/00498259109043201

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Transformation of dithiopyr by rat liver enzymes in vitro produced the corresponding monoacids as the predominant metabolites. 2. Transformations of the methylthioester functional groups in dithiopyr to the monoacids were mediated via rat liver microsomal oxygenases, and not via esterases. 3. Based on the formation of a dithiopyr-glutathione conjugate, the mechanism of monoacid formation is believed to proceed through an initial sulphur oxidation of the methylthioester group and a subsequent nucleophilic displacement reaction.

引用

页码：1265 / 1271

页数：7

共 9 条

[1]

BEAN MF, 1987, 35TH P ASMS C MASS S, P1104

[2] INVITRO OXIDATION OF 2,6-DIETHYLANILINE BY RAT-LIVER MICROSOMAL-ENZYMES [J].