OLIGONUCLEOTIDES WITH A NUCLEASE-RESISTANT SULFUR-BASED LINKAGE

被引：46

作者：

HUIE, EM ^{[1
]}

KIRSHENBAUM, MR ^{[1
]}

TRAINOR, GL ^{[1
]}

机构：

[1] DU PONT MERCK PHARMACEUT CO,DEPT BIOTECHNOL,EXPTL STN BOX 80328,WILMINGTON,DE 19880

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 17期

关键词：

D O I：

10.1021/jo00043a004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A pair of complementary oligonucleotides with an EcoR1 recognition sequence (GAATTC) bearing a novel sulfamate linkage at the cleavage site have been prepared and shown to be capable of annealing to form a stable duplex that is resistant to EcoR1 cleavage.

引用

页码：4569 / 4570

页数：2

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