THE NUMBER OF LUTEINIZING-HORMONE-RELEASING HORMONE IMMUNOREACTIVE NEURONS IS SIGNIFICANTLY DECREASED IN THE FOREBRAIN OF OLD-AGED FEMALE RATS

被引：23

作者：

FUNABASHI, T

KIMURA, F

机构：

[1] Department of Physiology, Yokohama City University School of Medicine, Kanazawa-ku, Yokohama, 236

来源：

NEUROSCIENCE LETTERS | 1995年 / 189卷 / 02期

关键词：

LUTEINIZING HORMONE-RELEASING HORMONE; AGING; SENESCENCE; IMMUNOCYTOCHEMISTRY; FEMALE RATS; PREOPTIC AREA; FOREBRAIN;

D O I：

10.1016/0304-3940(95)11457-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To see changes in the number of luteinizing hormone-releasing hormone (LHRH) neurons during aging, young (3 months old)- and old (26 months old)-aged female rats, four of each, were used 4 weeks after ovariectomy for immunocytochemistry. The estimated total number (mean +/- SEM) of LHRH immunoreactive (ir) neurons in the forebrain of old-aged rats (353 +/- 34) was significantly smaller than that in young-aged rats (672 +/- 51). In the forebrain, the decrease in the number of LHRH-ir neurons with age in rostral parts was greater than that in caudal parts, suggesting heterogeneous impairment of LHRH neurons in the rat forebrain during aging.

引用

页码：85 / 88

页数：4

共 23 条

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[2]

ALBEFESSARD D, 1966, ATLAS STEREOTAXIQUE

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