HYDROXYLATION OF 5H-3-OXO-2,3,6,7,8,9-HEXAHYDROIMIDAZO[1,2-A]AZEPINE DERIVATIVES BY MOLECULAR-OXYGEN

被引：7

作者：

CAMPAGNA, F

CAROTTI, A

CASINI, G

机构：

[1] Dipartimento Farmaco-Chimico, University of Bari, Bari, 70126

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 07期

关键词：

D O I：

10.1002/jhet.5570270723

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

O-Methylcaprolactim 3 reacts in hot dimethylsulfoxide with alpha-amino acids 4 to give 5H-3-oxo-2,3,6,7,8,9-hexahydroimidazo[1,2-a]azepines 6 and, unexpectedly, hydroxylated derivatives 7a,c and 8c. The structures of the hydroxylated compounds have been elucidated by spectroscopic means and, when necessary, further confirmed by an independent unequivocal synthesis. The formation of 7 as well as the isomerization of 7c to 8c are discussed in detail.

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页码：1973 / 1977

页数：5

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