A POSSIBLE MECHANISM OF ACTION OF THE NEUROTOXIC AGENT IMINODIPROPRIONITRILE (IDPN) - A SELECTIVE AGGREGATION OF THE MEDIUM AND HEAVY NEUROFILAMENT POLYPEPTIDES (NF-M AND NF-H)

被引：8

作者：

ANDERSON, JP

CARROLL, Z

SMULOWITZ, M

LIEBERBURG, I

机构：

[1] ATHENA NEUROSCI, 800-F GATEWAY BLVD, San Francisco, CA 94080 USA

[2] CUNY MT SINAI SCH MED, DEPT PSYCHIAT, NEW YORK, NY 10029 USA

[3] CUNY MT SINAI SCH MED, FISHBERG RES CTR NEUROBIOL, NEW YORK, NY 10029 USA

[4] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DIV ENDOCRINE, BRONX, NY 10461 USA

来源：

BRAIN RESEARCH | 1991年 / 547卷 / 02期

基金：

美国国家卫生研究院;

关键词：

IMINODIPROPRIONITRILE; NEUROFILAMENT; NEUROTOXICITY;

D O I：

10.1016/0006-8993(91)90986-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Juvenile male rats treated acutely with the neurotoxic agent, iminodiproprionitrile showed no changes in the levels of total neurofilament subunit mRNA or protein for up to 28 days. However, the drug promoted aggregation of the neurofilaments, both spontaneously upon isolation and in an in vitro reassembly assay. This observation correlated with a basic pI shift of the heavy neurofilament subunit, due to a yet to be identified modification. Because of the crucial involvement of this neurofilament subunit in axonal integrity, it is likely that iminodiproprionitrile produces a major portion of its neurotoxicity through this mechanism.

引用

收藏

页码：353 / 357

页数：5

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