ORGANIC-SYNTHESIS UTILIZING CHARACTERISTICS OF ORGANOSILICON COMPOUNDS

The generation of novel unstable active chemical species and their synthetic equivalents can be attained by novel and characteristic reactions of stable organosilicon compounds which are easily designed and prepared. On the basis of this concept, syntheses of synthetic equivalents such as highly functionalized new 1,3-dipolar reagents and thio carbanions can be applied to synthetic chemistry. Reactions of these species with a variety of dipolarophiles, heterodipolarophiles and electrophiles are found to afford functionalized heterocycles and their synthetic intermediates in highly regio- and stereoselective mode. This "tailor-made" methodology directed toward highly selective organic synthesis is described.