EPR SPIN-TRAPPING STUDY OF NITRIC-OXIDE FORMATION DURING BILATERAL CAROTID OCCLUSION IN THE RAT

被引：66

作者：

SATO, S ^{[1
]}

TOMINAGA, T ^{[1
]}

OHNISHI, T ^{[1
]}

OHNISHI, ST ^{[1
]}

机构：

[1] UNIV PENN,SCH MED,DEPT BIOCHEM & BIOPHYS,PHILADELPHIA,PA 19104

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1181卷 / 02期

关键词：

BRAIN ISCHEMIA; COMMON CAROTID OCCLUSION; EPR; NITRIC OXIDE (NO); SPIN-TRAPPING;

D O I：

10.1016/0925-4439(93)90111-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The formation of nitric oxide (NO) radicals was demonstrated by electron paramagnetic resonance spectroscopy in the rat during varying degrees of brain ischemia. Diethyldithiocarbamate and Fe-citrate were used as in vivo spin-trapping reagents. The signal of NO spin adducts increased in accordance with the degree of ischemic insults. The formation of NO radicals was inhibited by N(G)-nitro-L-arginine methyl ester.

引用

页码：195 / 197

页数：3

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