学术探索
学术期刊
新闻热点
数据分析
智能评审

RELATIONSHIP OF INTERLEUKIN-4 TO ISOTYPIC DISTRIBUTION OF ANTI-DOUBLE-STRANDED DNA ANTIBODIES IN SYSTEMIC LUPUS-ERYTHEMATOSUS

被引：16
作者：
DUEYMES, M
BARRIER, J
BESANCENOT, JF
CLEDES, J
CONRI, C
DIEN, G
DROSOS, AA
DUEYMES, JM
GALANAUD, P
GROBOIS, B
GUILLEVIN, L
HATRON, PY
ISENBERG, DA
JORGENSEN, C
JOUQUAN, J
LAMOUR, A
LEGOFF, P
LONGYBOURSIER, M
MARAN, R
MASSOT, C
MEYER, O
MOTTIER, D
MOUTSOPOULOS, HM
PHILIPPE, P
PIETTE, JC
SANY, J
SERIES, C
SHOENFELD, Y
YOUINOU, P
机构：
[1] BREST UNIV HOSP, SCH MED, IMMUNOL LAB, F-29609 BREST, FRANCE
[2] HOP C HURIEZ, MED CLIN A, LILLE, FRANCE
[3] HOP ST ELOI, SERV IMMUNORHUMATOL, MONTPELLIER, FRANCE
[4] CHU GRENOBLE, F-38043 GRENOBLE, FRANCE
[5] HOP BICHAT, RHUMATOL CLIN, F-75877 PARIS, FRANCE
[6] CHU CLERMONT FERRAND, SERV MED INTERNE, F-63003 CLERMONT FERRAND, FRANCE
[7] RES UNIT AUTOIMMUNE DIS, TEL HASHOMER, ISRAEL
[8] MED SCH IOANNINA, DEPT INTERNAL MED, IOANNINA, GREECE
[9] UNIV COLL & MIDDLESEX HOSP, SCH MED, DEPT RHEUMATOL, LONDON, ENGLAND
[10] CHU BORDEAUX, SERV MED INTERNE NEUROL, BORDEAUX, FRANCE
[11] CHU BORDEAUX, MED PROPEDEUT & MALAD TROP CLIN, BORDEAUX, FRANCE
[12] CHU BORDEAUX, SERV MED INTERNE & PATHOL, BORDEAUX, FRANCE
[13] CHG, SERV MED INTERNE & MALAD INFECT, ST BRIEUC, FRANCE
[14] CHU BREST, SERV NEPHROL, F-29279 BREST, FRANCE
[15] CHU BREST, MED HARVIER CLIN, F-29279 BREST, FRANCE
[16] CHU BREST, SERV RHUMATOL, F-29279 BREST, FRANCE
[17] CHU BREST, SERV SEBILEAU, F-29279 BREST, FRANCE
[18] HOP HOTEL DIEU, SERV MED INTERNE 2, F-44035 NANTES, FRANCE
[19] CHU DJION, SERV MED INTERNE, DJION, FRANCE
[20] HOP A BECHERE, SERV MED INTERNE, CLAMART, FRANCE
[21] HOP SUD, DEPT MED INTERNE, RENNES, FRANCE
[22] HOP AVICENNE, SERV MED INTERNE, BOBIGNY, FRANCE
来源：
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1993年 / 101卷 / 04期
关键词：
SYSTEMIC LUPUS ERYTHEMATOSUS; INTERLEUKIN-4; ANTI-DOUBLE-STRANDED DNA ANTIBODY;
D O I：
10.1159/000236484
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
IgG subclasses of anti-double-stranded DNA antibodies were determined in 182 patients with systemic lupus erythematosus. All isotypes were detected, but IgG1 and IgG3 were predominant (62 and 51% of the cases, respectively). An average of 64 +/- 27% was IgG1, 16 +/- 22% IgG2, 16 +/- 19% IgG3 and 4 +/- 10% IgG4. The rank order or frequency was IgG1, IgG3, IgG2 and IgG4 in patients with musculoskeletal involvement; IgG1, IgG2, IgG3 and IgG4 in those with renal complications; IgG3, IgG1, IgG2 and IgG4 in those with cutaneous involvement; and IgG1, IgG3, IgG2 and IgG4 in those with hematological manifestations. Interleukin-4 (IL-4) was dectectable in 17 of 36 selected patients, as opposed to 1 of 40 normal controls. The percentage of the total autoantibody contributed by IgG1 was significantly higher (p < 0.03) in these patients than in the remainder with undetectable levels of IL-4.
引用
收藏
页码：408 / 415
页数：8
相关论文
共 40 条
1234