CLINICAL CONCENTRATIONS OF VERAPAMIL AFFECT THE INVITRO DIAGNOSIS OF SUSCEPTIBILITY TO MALIGNANT HYPERPYREXIA

被引:6
作者
ADNET, PJ
KRIVOSICHORBER, RM
ADAMANTIDIS, MM
HAUDECOEUR, G
REYFORT, GH
DUPUIS, BA
机构
[1] CHU LILLE, DEPT ANESTHESIE REANIMAT, F-59037 LILLE, FRANCE
[2] CHU LILLE, FAC MED, PHARMACOL HOSP LAB, F-59037 LILLE, FRANCE
关键词
Malignant hyperpyrexia; Pharmacology:; verapamil; halothane; caffeine;
D O I
10.1093/bja/64.1.64
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
We examined the effects of verapamil on the in vitro caffeine and halothane tests for malignant hyperpyrexia (MH) susceptibility. Ten consecutive MH-susceptible patients were investigated according to the protocol of the European MH group. Additional tests were carried out in the presence of verapamil 10-6 mol litre-1. In four of the 10 patients, the halothane contracture response following pretreatment with verapamil was classified as positive to halothane. In contrast, in nine of the 10 patients, contracture tests of muscle in the presence of verapamil were classified as negative to caffeine. It is advised that verapamil should be discontinued before performing a contracture test. © 1990 Copyright: 1990 British Journal of Anaesthesia.
引用
收藏
页码:64 / 66
页数:3
相关论文
共 16 条
[1]  
ADNET P, 1988, EUR J ANAESTH, V5, P342
[2]   PLASMA-CONCENTRATION - RESPONSE RELATIONSHIP OF VERAPAMIL IN THE TREATMENT OF ANGINA-PECTORIS [J].
ANDERSON, P ;
BONDESSON, U ;
SYLVEN, C ;
ASTROM, H .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1982, 4 (04) :609-614
[3]  
BRAUNWALD E, 1982, NEW ENGL J MED, V307, P1618
[4]   VERAPAMIL AND ZERO CA-2+ ALTER RESPONSES OF CAT MUSCLE TO HALOTHANE AND CAFFEINE [J].
DEUSTER, PA ;
BOCKMAN, EL ;
BISCARDI, H ;
MULDOON, SM .
JOURNAL OF APPLIED PHYSIOLOGY, 1986, 60 (03) :935-941
[5]  
ELLIS FR, 1984, BRIT J ANAESTH, V56, P1267
[6]   SCREENING FOR MALIGNANT HYPERPYREXIA [J].
ELLIS, FR ;
MULROONEY, PL ;
KYEIMENS.K ;
TYRRELL, JH ;
SUMNER, DW ;
HARRIMAN, DG ;
HARGREAVES, JB ;
PARIKH, RK ;
KEANEY, NP .
BMJ-BRITISH MEDICAL JOURNAL, 1972, 3 (5826) :559-+
[7]  
GALLANT EM, 1985, ANESTH ANALG, V64, P601
[8]  
GRUENER R, 1980, MOL MECHANISMS ANEST, P423
[9]   CAFFEINE TEST OF ISOLATED HUMAN MUSCLE IN RELATION TO MALIGNANT HYPERTHERMIA [J].
KALOW, W ;
BRITT, BA ;
RICHTER, A .
CANADIAN ANAESTHETISTS SOCIETY JOURNAL, 1977, 24 (06) :678-694
[10]   STUDY OF ACTION OF CAFFEINE, HALOTHANE, POTASSIUM-CHLORIDE AND PROCAINE ON NORMAL HUMAN SKELETAL-MUSCLE [J].
MOULDS, RFW ;
DENBOROUGH, MA .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1974, 1 (03) :197-209