PI TRAPPING IN GLYCOGENOLYTIC PATHWAY CAN EXPLAIN TRANSIENT PI DISAPPEARANCE DURING RECOVERY FROM MUSCULAR EXERCISE - A P-31 NRM STUDY IN THE HUMAN

被引：46

作者：

BENDAHAN, D ^{[1
]}

CONFORTGOUNY, S ^{[1
]}

KOZAKREISS, G ^{[1
]}

COZZONE, PJ ^{[1
]}

机构：

[1] FAC MED MARSEILLE, CTR RESONANCE MAGNET BIOL & MED, 27 BD JEAN MOULIN, F-130005 MARSEILLE, FRANCE

来源：

FEBS LETTERS | 1990年 / 269卷 / 02期

关键词：

Human muscle; In vivo NMR spectroscopy; Inorganic phosphate; Phosphomonoester; Phosphorylated metabolite;

D O I：

10.1016/0014-5793(90)81203-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

31P NMR spectroscopy at 4.7 T has been used to follow changes in phosphorylated metabolites and pHi in the flexor digitorum superficialis muscle of 15 healthy volunteers subjected to a rest-exercise-recovery protocol. Phosphomonoesters (Pme) increased during exercise and exhibited a delayed recovery to resting level. During early recovery, Pi fell below resting concentration without correlated PCr oversynthesis while Pme level stayed above its resting value. The sum Pi + Pme remained constant. These observations suggest that Pi could be trapped into the glycogenolytic pathway during exercise leading to Pme production. This trapping and the slow Pme recovery could account for transient Pi disappearance observed during recovery. © 1990.

引用

页码：402 / 405

页数：4

共 16 条

[1] MAPPING OF METABOLITES IN WHOLE ANIMALS BY P-31 NMR USING SURFACE COILS [J].