AN INTRAMOLECULAR DIELS-ALDER APPROACH TO THE SYNTHESIS OF CHLOROTHRICOLIDE - SYNTHESIS OF (+/-)-24-O-METHYLCHLOROTHRICOLIDE

被引：44

作者：

TAKEDA, K

IGARASHI, Y

OKAZAKI, K

YOSHII, E

YAMAGUCHI, K

机构：

[1] TOYAMA MED & PHARMACEUT UNIV,FAC PHARMACEUT SCI,SUGITANI 2630,SUGITANI,TOYAMA 93001,JAPAN

[2] SHOWA UNIV,SCH PHARMACEUT SCI,SHINAGAWA KU,TOKYO 142,JAPAN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 11期

关键词：

D O I：

10.1021/jo00298a003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

: Cycloaddition of a-(acyloxy)-7-methylene-0-tetronate 16, obtained by condensation of three segments ((±)-ll, 12, and 15), affords four diastereomeric macrolides 17a-d (1:2.8:1.9:0.9 ratio). The exo mode adduct 17a has been converted to (±)-24-0-methylchIorothricolide (19). © 1990, American Chemical Society. All rights reserved.

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页码：3431 / 3434

页数：4

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