POKEWEED ANTIVIRAL PROTEIN - RIBOSOME INACTIVATION AND THERAPEUTIC APPLICATIONS

被引：102

作者：

IRVIN, JD

UCKUN, FM

机构：

[1] UNIV MINNESOTA,DEPT THERAPEUT RADIOL RADIAT ONCOL,MINNEAPOLIS,MN 55455

[2] UNIV MINNESOTA,DEPT PHARMACOL,MINNEAPOLIS,MN 55455

[3] UNIV MINNESOTA,DEPT PEDIAT,MINNEAPOLIS,MN 55455

来源：

PHARMACOLOGY & THERAPEUTICS | 1992年 / 55卷 / 03期

关键词：

D O I：

10.1016/0163-7258(92)90053-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pokeweed antiviral protein (PAP) is a ribosome-inactivating protein (RIP) that inactivates ribosomes by the removal of a single adenine from ribosomal RNA. The studies summarized in our review concern the nature and application of this novel therapeutic agent. We describe how researchers continue to elucidate the structure and biologic activity of RIPs. Pokeweed antiviral protein is among the RIPs that have been conjugated to selective monoclonal antibodies for the treatment of several human cancers and viral diseases. Clinical trials using PAP immunotoxins for the treatment of leukemia have been particularly encouraging.

引用

页码：279 / 302

页数：24

共 128 条

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[2]

ARON GM, 1988, CYTOBIOS, V55, P105

[3] PURIFICATION AND PARTIAL CHARACTERIZATION OF ANOTHER FORM OF THE ANTIVIRAL PROTEIN FROM THE SEEDS OF PHYTOLACCA-AMERICANA L (POKEWEED) [J].