CONSERVED ORGANIZATION OF GENES FOR BIOSYNTHESIS OF CHLORTETRACYCLINE IN STREPTOMYCES STRAINS

被引：5

作者：

DAIRI, T ^{[1
]}

NAKANO, T ^{[1
]}

MIZUKAMI, T ^{[1
]}

AISAKA, K ^{[1
]}

HASEGAWA, M ^{[1
]}

KATSUMATA, R ^{[1
]}

机构：

[1] KYOWA HAKKO KOGYO CO LTD, TOKYO RES LABS, MACHIDA, TOKYO 194, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1995年 / 59卷 / 07期

关键词：

D O I：

10.1271/bbb.59.1360

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By genomic Southern blot analysis, the DNA sequences homologous to the gene cluster responsible for biosynthesis of 6-demethyl-chlortetracycline in Streptomyces aureofaciens NRRL3203 mere shown to be highly conserved in independent chlortetracycline- or tetracycline producing Streptomyces strains. By contrast, oxytetracycline-producing Streptomyces strains had no hybridization with the cluster DNA.

引用

页码：1360 / 1361

页数：2

共 8 条

[1]

BALDACCI E, 1969, INT J SYST BACTERIOL, V19, P391

[2] CLONING AND NUCLEOTIDE-SEQUENCE OF THE GENE RESPONSIBLE FOR CHLORINATION OF TETRACYCLINE [J].

DAIRI, T ;

NAKANO, T ;

AISAKA, K ;

KATSUMATA, R ;

HASEGAWA, M .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1995, 59 (06) :1099-1106

[3] STREPTOMYCIN BIOSYNTHESIS AND ITS REGULATION IN STREPTOMYCETES [J].

DISTLER, J ;

MANSOURI, K ;

MAYER, G ;

STOCKMANN, M ;

PIEPERSBERG, W .

GENE, 1992, 115 (1-2) :105-111

[4]

HOSTALEK Z, 1986, BIOTECHNOLOGY, V4, P393

[5]

THIRUMALACHAR MJ, 1980, INT J SYST BACTERIOL, V30, P225

[6]

VIRGILIO A, 1962, Patent No. 3070514

[7] CLONING AND EXPRESSION IN ESCHERICHIA-COLI OF ISOPENICILLIN-N SYNTHETASE GENES FROM STREPTOMYCES-LIPMANII AND ASPERGILLUS-NIDULANS [J].

WEIGEL, BJ ;

BURGETT, SG ;

CHEN, VJ ;

SKATRUD, PL ;

FROLIK, CA ;

QUEENER, SW ;

INGOLIA, TD .

JOURNAL OF BACTERIOLOGY, 1988, 170 (09) :3817-3826

[8] IDENTIFICATION AND CHARACTERIZATION OF PHOSPHINOTHRICIN-TRIPEPTIDE BIOSYNTHETIC GENES IN STREPTOMYCES-VIRIDOCHROMOGENES [J].

WOHLLEBEN, W ;

ALIJAH, R ;

DORENDORF, J ;

HILLEMANN, D ;

NUSSBAUMER, B ;

PELZER, S .

GENE, 1992, 115 (1-2) :127-132

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