SYNTHESIS AND GASTRIC ANTISECRETORY PROPERTIES OF ALPHA-CHAIN DIENE DERIVATIVES OF MISOPROSTOL

被引:10
作者
COLLINS, PW [1 ]
GASIECKI, AF [1 ]
JONES, PH [1 ]
BAUER, RF [1 ]
GULLIKSON, GW [1 ]
WOODS, EM [1 ]
BIANCHI, RG [1 ]
机构
[1] GD SEARLE & CO,DEPT BIOL RES,SKOKIE,IL 60077
关键词
D O I
10.1021/jm00157a013
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1195 / 1201
页数:7
相关论文
共 14 条
[1]   SYNTHESIS AND GASTRIC ANTI-SECRETORY PROPERTIES OF 4,5-UNSATURATED DERIVATIVES OF 15-DEOXY-16-HYDROXY-16-METHYLPROSTAGLANDIN-E1 [J].
COLLINS, PW ;
DAJANI, EZ ;
PAPPO, R ;
GASIECKI, AF ;
BIANCHI, RG ;
WOODS, EM .
JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (06) :786-790
[2]   SYNTHESIS AND GASTRIC ANTISECRETORY PROPERTIES OF 15-DEOXY-16-HYDROXYPROSTAGLANDIN E ANALOGS [J].
COLLINS, PW ;
DAJANI, EZ ;
DRISKILL, DR ;
BRUHN, MS ;
JUNG, CJ ;
PAPPO, R .
JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (09) :1152-1159
[3]   PROTECTION OF HYDROXYL GROUPS AS TERT-BUTYLDIMETHYLSILYL DERIVATIVES [J].
COREY, EJ ;
VENKATESWARLU, A .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1972, 94 (17) :6190-+
[4]   EFFECTS OF E-PROSTAGLANDINS, DIPHENOXYLATE AND MORPHINE ON INTESTINAL MOTILITY INVIVO [J].
DAJANI, EZ ;
ROGE, EAW ;
BERTERMANN, RE .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1975, 34 (01) :105-113
[5]  
FINNEY DJ, 1976, J PHARMACOL EXP THER, V198, P487
[6]  
FISHER RA, 1970, STATISTICAL METHODS, pCH9
[7]   DECREASED RATE OF METABOLISM INDUCED BY A SHIFT OF DOUBLE-BOND IN PROSTAGLANDIN F-2ALPHA FROM DELTA-5 TO DELTA-4 POSITION [J].
GREEN, K ;
SAMUELSSON, B ;
MAGERLEIN, BJ .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1976, 62 (03) :527-537
[8]   PROSTAGLANDIN ANALOGS POSSESSING ANTINIDATORY EFFECTS .2. MODIFICATION OF THE ALPHA-CHAIN [J].
HAYASHI, M ;
ARAI, Y ;
WAKATSUKA, H ;
KAWAMURA, M ;
KONISHI, Y ;
TSUDA, T ;
MATSUMOTO, K .
JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (05) :525-535
[9]   EFFECT OF ORALLY ADMINISTERED PROSTAGLANDIN E1 ON GASTRIC SECRETION AND GASTROINTESTINAL MOTILITY IN MAN [J].
HORTON, EW ;
MAIN, IHM ;
THOMPSON, CJ ;
WRIGHT, PM .
GUT, 1968, 9 (06) :655-&
[10]   TERMINATION OF PREGNANCY WITH PROSTAGLANDIN-E2 METHYL-ESTER [J].
KARIM, SMM ;
AMY, JJ .
PROSTAGLANDINS, 1974, 7 (04) :293-302