RECOMBINANT INTERFERON-ALPHA-2B IN THE TREATMENT OF DIFFUSE MALIGNANT PLEURAL MESOTHELIOMA

被引:24
作者
ARDIZZONI, A
PENNUCCI, MC
CASTAGNETO, B
MARIANI, GL
CINQUEGRANA, A
MAGRI, D
VERNA, A
SALVATI, F
ROSSO, R
机构
[1] OSPED S SPIRITO CASALE MONFERRATO,DEPT MED,CASALE MONFERRATO,ITALY
[2] OSPED SAN MARTINO GENOVA,GENOA,ITALY
[3] CTR RIFERIMENTO ONCOL AVIANO,DEPT MED ONCOL,AVIANO,ITALY
[4] OSPED FORALNINI,ROME,ITALY
来源
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 1994年 / 17卷 / 01期
关键词
MALIGNANT MESOTHELIOMA; MEDICAL TREATMENT; INTERFERONS;
D O I
10.1097/00000421-199402000-00018
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Fourteen patients with diffuse malignant pleural mesothelioma (DMPM) were enrolled in a Phase II study to assess activity and toxicity of the systemic administration of recombinant (r)-alpha-interferon (IFN)-2b. The IFN schedule was: 3 X 10(6) IU i.m. days 1-4, 6 X 10(6) IU days 5-8, 10 X 10(6) IU days 9-12; then IFN was administered at 10 X 10(6) IU 3 days/week. If grades II-III toxicity occurred, IFN dose was reduced and drug continued at the previous dose level. All patients were evaluated by CT scan. Only one patient was not evaluable for response and toxicity because of inadequate followup. Of 13 evaluable patients, we observed 1 objective response, 6 stable disease, and 6 failures (3 progressive disease and 3 early interruptions due to subjective toxicity). The median time to progression was 19 weeks, and the median overall survival was 62 weeks. Toxicity was mild: of 13 patients evaluable for toxicity we observed fever (9 patients), flu-like syndrome (3 patients), fatigue (4 patients), anorexia (2 patients), myelosuppression (3 patients), and muscle pain (1 patient). The results of this study indicate only marginal activity of r-alpha-IFN in the treatment of DMPM.
引用
收藏
页码:80 / 82
页数:3
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