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PROTOTYPE, SOLID-PHASE, GLUCOSE BIOSENSOR
被引：49
作者：
GILMARTIN, MAT
[1
]
HART, JP
[1
]
PATTON, DT
[1
]
机构：
[1] UNIV W ENGLAND,FAC SCI APPL,BRISTOL BS16 1QY,AVON,ENGLAND
来源：
关键词：
DISPOSABLE PRINTED BIOSENSOR;
GLUCOSE;
HYDROGEN PEROXIDE;
SELECTIVITY-ENHANCING TECHNIQUE;
SCANNING ELECTRON MICROSCOPY;
D O I：
10.1039/an9952001973
中图分类号：
O65 [分析化学];
学科分类号：
070302 ;
081704 ;
摘要：
A single-shot reagentless biosensor for the amperometric determination of glucose is described. The device has been produced in a novel dual-electrode configuration, whereby the working and reference/counter electrodes are printed alongside one another in a disposable format. The biosensor is based on a cobalt phthalocyanine-containing screen-printed carbon electrode coated with cellulose acetate and glucose oxidase (GOD). The organometallic redox mediator permits the detection of GOD-evolved H2O2 at markedly reduced (< 0.5 V, Ag/AgCl) overvoltages. The selectivity is further enhanced by the production of a solvent-cast, H2O2-permeable film directly over the sensor assembly, serving to screen out interferents and electrode-fouling agents. Voltammetry and amperometry have been used to optimize the sensor's analytical performance and SEM to investigate the efficacy of producing the chemical and biological layers.
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页码：1973 / 1981
页数：9
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