ROLE OF VITAMIN-A IN LIVER FIBROSIS

被引：14

作者：

KNOOK, DL

BOSMA, A

SEIFERT, WF

机构：

[1] TNO Institute of Ageing and Vascular Research, Leiden

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 1995年 / 10卷

关键词：

BETA-CAROTENE; CCL4; CIRRHOSIS; COLLAGEN METABOLISM; FAT-STORING CELLS; FIBROGENESIS; FIBROSIS; VITAMIN-A;

D O I：

10.1111/j.1440-1746.1995.tb01797.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The relationship between vitamin A and liver fibrosis was studied with a CCl4-induced fibrosis model in rats. Depending on the time of administration, vitamin A can potentiate or reduce fibrosis: when present during CCl4-treatment parenchymal cell damage and fibrosis were enhanced, whereas vitamin A post-treatment strongly reduced fibrosis. Enhanced fibrosis was also found in rats with low hepatic retinoid levels. Administration of beta-carotene during CCl4-treatment reduced several signs of fibrosis. The notion that liver retinoids play an important role in hepatic fibrogenesis is discussed.

引用

页码：S47 / S49

页数：3

共 16 条

[1] CHRONIC ADMINISTRATION OF ETHANOL WITH HIGH VITAMIN-A SUPPLEMENTATION IN A LIQUID DIET TO RATS DOES NOT CAUSE LIVER FIBROSIS .1. MORPHOLOGICAL OBSERVATIONS [J].