LYMPHOEPITHELIOMA-LIKE CARCINOMA OF THE LUNG - ANALYSIS OF 2 CASES FOR EPSTEIN-BARR-VIRUS INFECTION

被引：31

作者：

HIGASHIYAMA, M ^{[1
]}

DOI, O ^{[1
]}

KODAMA, K ^{[1
]}

YOKOUCHI, H ^{[1
]}

TATEISHI, R ^{[1
]}

HORIUCHI, K ^{[1
]}

MISHIMA, K ^{[1
]}

机构：

[1] NARA MED UNIV,DEPT PATHOL 1,KASHIHARA,NARA 634,JAPAN

来源：

HUMAN PATHOLOGY | 1995年 / 26卷 / 11期

关键词：

LYMPHOEPITHELIOMA-LIKE CARCINOMA; EPSTEIN-BARR VIRUS; LUNG CARCINOMA;

D O I：

10.1016/0046-8177(95)90206-6

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Lymphoepithelioma-like carcinoma, which is an uncommon histological type of epithelial tumor, has been described as being closely associated with Epstein-Barr virus (EBV) infection in organs other than the lung. Recently, we experienced two surgically resected cases of pulmonary tumors mimicking lymphoepithelioma-like carcinoma. Both cases contained EBV DNA genomes as shown by polymerase chain reaction (PCR) using EBV DNA-specific primers, one positive for EBV DNA in virtually all cancer cells, and the other showing positive hybridization in a small number of cancer cells by in situ hybridization (ISH) using digoxigenin-labeled olignucletide probes for each of EBV DNA for EBV DNA. EBV-encoded RNA-1 (EBER-1) was typically detected in one case, These results are highly suggestive of EBV-associated tumors in one of the current cases, although in the other case, no such close association was determined. It seems that lymphoepithelioma-like pulmonary carcinoma, which seems extremely unusual, may be closely associated with EBV infection in tumorigenesis. Copyright (C) 1995 by W.B. Saunders Company

引用

页码：1278 / 1282

页数：5

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