A SYNTHETIC PEPTIDE DERIVED FROM THE AMINO-ACID-SEQUENCE OF CANINE PARVOVIRUS STRUCTURAL PROTEINS WHICH DEFINES A B-CELL EPITOPE AND ELICITS ANTIVIRAL ANTIBODY IN BALB C MICE

被引：23

作者：

RIMMELZWAAN, GF ^{[1
]}

CARLSON, J ^{[1
]}

UYTDEHAAG, FGCM ^{[1
]}

OSTERHAUS, ADME ^{[1
]}

机构：

[1] COLORADO STATE UNIV,DEPT MICROBIOL,FT COLLINS,CO 80523

来源：

JOURNAL OF GENERAL VIROLOGY | 1990年 / 71卷

关键词：

D O I：

10.1099/0022-1317-71-11-2741

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Synthetic peptides, recombinant fusion proteins and mouse monoclonal antibodies were used to delineate a B cell epitope of the VP2' structural protein of canine parvovirus (CPV). Although this epitope is not preferentially recognized in the normal antibody response to CPV, virus-specific antibodies could be induced in BALB/c mice with a synthetic peptide representing the epitope. The potential of this non-dominant B cell epitope to induce antiviral immunity in the presence of maternal CPV-specific antibodies, is discussed.

引用

页码：2741 / 2745

页数：5

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