THE BIOSYNTHESIS OF XANTHOCILLIN-X MONOMETHYL ETHER IN DICHOTOMOMYCES-CEJPII - EXPERIMENTS ON THE ORIGIN OF THE ISOCYANIDE CARBON-ATOMS

被引：12

作者：

CABLE, KM ^{[1
]}

HERBERT, RB ^{[1
]}

KNAGGS, AR ^{[1
]}

MANN, J ^{[1
]}

机构：

[1] UNIV LEEDS,SCH CHEM,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1991年 / 03期

关键词：

D O I：

10.1039/p19910000595

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Precursor feeding experiments establish that the isocyanide groups in xanthocillin-X monomethyl ether (XME) 1 do not originate from (i) compounds associated with C1-tetrahydrofolate metabolism; (ii) the ureido group of citrulline, carbamoyl phosphate, or potassium cyanate; or (iii) cyanide and arguably related compounds. However the results with D-[U-C-13]glucose show that the origin of the isocyanide groups is metabolically closer to glucose than is the origin of the backbone; DL-[1-C-13]-glyceraldehyde and D-[1-C-13]glucose are not specific precursors.

引用

页码：595 / 599

页数：5

共 32 条

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