CHROMOSOMAL-ABNORMALITIES IN DUPUYTREN CONTRACTURE AND CARPAL-TUNNEL SYNDROME

被引：63

作者：

BONNICI, AV

BIRJANDI, F

SPENCER, JD

FOX, SP

BERRY, AC

机构：

[1] From the Departments of Orthopaedics and Clinical Genetics, Guy's Hospital

[2] Department of Orthopaedics, St. Thomas' Hospital, London, SE1 7EH, Lambeth Palce Road

来源：

JOURNAL OF HAND SURGERY-BRITISH AND EUROPEAN VOLUME | 1992年 / 17B卷 / 03期

关键词：

D O I：

10.1016/0266-7681(92)90128-O

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The cytogenetics of cell cultures derived from Dupuytren's tissue, adjacent palmar fascia and palmar skin from patients undergoing fasciectomy have been examined and the results compared to cell cultures established from palmar fascia, flexor retinaculum and palmar skin of patients undergoing carpal tunnel decompression. Chromosomal abnormalities were detected in cell cultures from Dupuytren's tissue in eight of the nine patients studied. Clones of cells trisomic for chromosome 8 were found in five of the nine patients. Trisomy 8 was also present in two of five flexor retinaculum cultures from carpal tunnel syndrome cases. These findings in both Dupuytren's contracture and carpal tunnel syndrome suggest the presence of chromosomal instability in the palmar fascia. The significance of the chromosomal abnormalities is however unclear, but they indicate a possible common pathway in the onset of pathological fibrosis.

引用

页码：349 / 355

页数：7

共 18 条

[1] Bateman, Sanger, Armitage, Missing Y chromosome in lymph nodes from patients with non-Hodgkin's lymphoma, Cancer Genetics and Cytogenetics, 25, pp. 219-225, (1987)
[2] Bowser-Riley, Bain, Noble, Lamb, Chromosome abnormalities in Dupuytren's disease, Lancet, 2, pp. 1282-1283, (1975)
[3] Brickley-Parsons, Glimcher, Smith, Albin, Adams, Biochemical changes in the collagen of the palmar fascia in patients with Dupuytren's disease, Journal of Bone and Joint Surgery, 63 A, 5, pp. 787-797, (1981)
[4] Hueston, Dupuytren's contracture, Flynn's Hand Surgery, pp. 864-889, (1991)
[5] James, The genetic pattern of Dupuytren's disease and idiopathic epilepsy, Dupuytren's Disease, pp. 94-99, (1985)
[6] Ling, The genetic factors in Dupuytren's disease, Journal of Bone and Joint Surgery, 45 B, 4, pp. 709-718, (1963)
[7] Logan, Seizinger, Atkins, Martuza, Loss of the Y chromosome in meningiomas. A molecular genetic approach, Cancer Genetics and Cytogenetics, 45, pp. 41-47, (1990)
[8] Mark, Dahlenfors, Cytogenetical observations in 100 human benign pleomorphic adenomas: specificity of the chrmosomal aberrations and their relationship to sites of localized oncogenes, Anticancer Research, 6, pp. 299-309, (1986)
[9] Obe, Gobel, Engeln, Herha, Natarajan, Chromosomal aberrations in peripheral lymphocytes of alcoholics, Mutation Research, 73, pp. 377-386, (1980)
[10] Ochi, Douglass, Sandberg, Cytogenetic studies in primary gastric cancer, Cancer Genetics and Cytogenetics, 22, pp. 295-307, (1986)

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