TUNABLE DIODE-LASER SPECTROSCOPY FOR ISOTOPE ANALYSIS - DETECTION OF ISOTOPIC CARBON-MONOXIDE IN EXHALED BREATH

被引:13
作者
LEE, PS [1 ]
MAJKOWSKI, RF [1 ]
PERRY, TA [1 ]
机构
[1] GM CORP,DEPT PHYS,WARREN,MI 48090
关键词
D O I
10.1109/10.88442
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A high resolution tunable infrared diode laser spectroscopy system was developed for isotope analysis with sensitivity at ppb levels. Such a system is ideally suited for detection and measurement of minute amounts of infrared active compounds present in a huge noninfrared active background such as air. The operation and capabilities of the system were demonstrated by measuring physiological levels of isotopic carbon monoxide, (CO)-C-12-O-16 and (CO)-C-13-O-16, naturally present in exhaled human breath with essentially no sample preparation. The simplicity in obtaining such data suggests that fundamental physiological information may be derived from noninvasive measurements. This makes the system potentially useful for many biomedical applications.
引用
收藏
页码:966 / 973
页数:8
相关论文
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