COMPARATIVE PROTEIN MODELING BY SATISFACTION OF SPATIAL RESTRAINTS

被引：206

作者：

SALI, A

机构：

来源：

MOLECULAR MEDICINE TODAY | 1995年 / 1卷 / 06期

关键词：

D O I：

10.1016/s1357-4310(95)91170-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Approximately one third of known protein sequences are related to at least one known protein structure. As a result, an order of magnitude more sequences can be modeled by comparative modeling than there are experimentally determined protein structures, A large fraction of these models has an accuracy approaching that of a low resolution X-ray structure or a medium resolution nuclear magnetic resonance structure. The number of applications where homology modeling has been proven useful is growing rapidly.

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页码：270 / 277

页数：8

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