MEASUREMENT OF GASTROINTESTINAL PH AND REGIONAL TRANSIT TIMES IN NORMAL-CHILDREN

被引:84
作者
FALLINGBORG, J [1 ]
CHRISTENSEN, LA [1 ]
INGEMANNIELSEN, M [1 ]
JACOBSEN, BA [1 ]
ABILDGAARD, K [1 ]
RASMUSSEN, HH [1 ]
RASMUSSEN, SN [1 ]
机构
[1] AALBORG HOSP N, DEPT DIAGNOST RADIOL, DK-9000 AALBORG, DENMARK
关键词
Children; Colonic transit time; Gastrointestinal pH; Gastrointestinal transit time; Small intestinal transit time;
D O I
10.1097/00005176-199008000-00010
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Gastrointestinal pH and regional intestinal transit times of a capsule were measured in twelve healthy children aged 8-14 years using a radiotransmitting pH-sensitive capsule. The location of the capsule was determined by fluoroscopy. pH in the stomach was 1.5, but rose to 6.4 in the duodenum (mean values). pH gradually rose in the small intestine and reached an alkaline peak value of 7.4 in the distal part. pH dropped to 5.9 in the cecum but rose to 6.5 in the rectum. Median gastric residence time of the capsule was 1.1 h. Small intestinal transit time was 7.5 h, and colonic transit time was 17.2 h. pH profile and intestinal transit times found in the present study are almost identical to values found in studies on healthy adults. It is therefore concluded that the release pattern of pH-dependent sustained-release tablets in children is likely to be equal to that of adults. © 1990 Raven Press Ltd, New York.
引用
收藏
页码:211 / 214
页数:4
相关论文
共 21 条
[1]   SEGMENTAL COLONIC TRANSIT-TIME [J].
ARHAN, P ;
DEVROEDE, G ;
JEHANNIN, B ;
LANZA, M ;
FAVERDIN, C ;
DORNIC, C ;
PERSOZ, B ;
TETREAULT, L ;
PEREY, B ;
PELLERIN, D .
DISEASES OF THE COLON & RECTUM, 1981, 24 (08) :625-629
[2]   INVESTIGATIONS ON THE BACTERIAL FLORA, PH, AND SUGAR CONTENT IN THE INTESTINAL TRACT OF INFANTS [J].
BARBERO, GJ ;
RUNGE, G ;
FISCHER, D ;
CRAWFORD, MN ;
TORRES, FE ;
GYORGY, P .
JOURNAL OF PEDIATRICS, 1952, 40 (02) :152-163
[3]  
BECHGAARD H, 1982, ACTA PHARM TECHNOL, V28, P149
[4]  
BECKETT AH, 1987, ARZNEIMITTEL-FORSCH, V37-1, P221
[5]  
COLSON RH, 1981, BIOTELEM PAT MON, V8, P213
[6]   A COMPARATIVE-STUDY OF THE GASTROINTESTINAL TRANSIT OF A PELLET AND TABLET FORMULATION [J].
DAVIS, SS ;
HARDY, JG ;
TAYLOR, MJ ;
WHALLEY, DR ;
WILSON, CG .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1984, 21 (02) :167-177
[7]   TRANSIT OF PHARMACEUTICAL DOSAGE FORMS THROUGH THE SMALL-INTESTINE [J].
DAVIS, SS ;
HARDY, JG ;
FARA, JW .
GUT, 1986, 27 (08) :886-892
[8]   COLONIC RELEASE OF 5-AMINO SALICYLIC-ACID FROM AN ORAL PREPARATION IN ACTIVE ULCERATIVE-COLITIS [J].
DEW, MJ ;
RYDER, REJ ;
EVANS, N ;
EVANS, BK ;
RHODES, J .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1983, 16 (02) :185-187
[9]   MEASUREMENT OF GASTROINTESTINAL PH PROFILES IN NORMAL AMBULANT HUMAN-SUBJECTS [J].
EVANS, DF ;
PYE, G ;
BRAMLEY, R ;
CLARK, AG ;
DYSON, TJ ;
HARDCASTLE, JD .
GUT, 1988, 29 (08) :1035-1041
[10]  
FALLINGBORG J, 1989, ALIMENT PHARM THERAP, V3, P605