2 SULFONATED DYE COMPOUNDS WHICH COMPETE FOR INOSITOL 1,4,5-TRISPHOSPHATE BINDING TO RAT-LIVER MICROSOMES - EFFECTS ON 5'-PHOSPHATASE ACTIVITY

被引：11

作者：

BOOTMAN, MD ^{[1
]}

PAY, GF ^{[1
]}

RICK, CE ^{[1
]}

TONES, MA ^{[1
]}

机构：

[1] CIBA GEIGY PHARMACEUT CORP,THROMBOSIS RES UNIT,WIMBLEHURST RD,HORSHAM RH12 4AB,W SUSSEX,ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 166卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)91012-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of heparin to interact with the Ins 1,4,5-P3 receptor is dependent on its chain length and degree of sulphation. Here we report results obtained with two sulphonated dye compounds of known structures and molecular weights below 1000, Cibacron blue and Patent blue. Both compounds compete for Ins 1,4,5-P3 binding to rat liver microsomes and also inhibit Ins 1,4,5-P3 5′-phosphatase activity in the same preparation. Comparison with the effects of heparin show these to be two separate actions of the compounds. © 1990.

引用

页码：1334 / 1339

页数：6

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