ANALYSIS OF NA-23 NMR-SPECTRA FROM ISOLATED PERFUSED HEARTS

被引：25

作者：

KOHLER, SJ ^{[1
]}

PERRY, SB ^{[1
]}

STEWART, LC ^{[1
]}

ATKINSON, DE ^{[1
]}

CLARKE, K ^{[1
]}

INGWALL, JS ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,BOSTON,MA 02115

来源：

MAGNETIC RESONANCE IN MEDICINE | 1991年 / 18卷 / 01期

关键词：

D O I：

10.1002/mrm.1910180104

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The 23Na NMR spectra obtained from isolated hearts perfused with buffer containing the paramagnetic shift reagent dysprosium triethylenetetraminehexaacetic acid, Dy(TTHA)3−, are complex and contain a number of overlapping peaks of different intensities. Spectra from rat, rabbit, guinea pig, and ferret hearts obtained during periods of control perfusion are similar and undergo similar changes when the hearts are subjected to periods of ischemia and reflow. The contributions from the intracellular, interstitial, vascular, and bath compartments to the multiple peaks in the spectra of rat hearts have been assigned. The significant contributions to these spectra of bulk magnetic susceptibility effects and incomplete mixing have been demonstrated through a series of modeling experiments. Since the spectra from hearts of different species are so similar, the peak assignments made for the rat are applicable to spectra from rabbit, guinea pig, and ferret hearts as well. This work provides a framework for quantitative analysis of the spectral changes which occur during conditions such as ischemia and reflow. © 1991 Academic Press. Inc. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company

引用

页码：15 / 27

页数：13

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