THE METABOTROPIC EXCITATORY AMINO-ACID RECEPTOR AGONIST 1S,3R-ACPD SELECTIVELY POTENTIATES N-METHYL-D-ASPARTATE-INDUCED BRAIN INJURY

被引:99
作者
MCDONALD, JW
SCHOEPP, DD
机构
[1] CNS Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN
关键词
EXCITOTOXICITY; EXCITATORY AMINO ACID; METABOTROPIC RECEPTORS;
D O I
10.1016/0014-2999(92)90058-C
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The role of metabotropic type excitatory amino acid receptors in brain injury was assessed using the selective metabotropic receptor agonist, (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). Intrastriatal stereotaxic injection of 1S,3R-ACPD (250 nmol) in PND 7 rats produced little brain injury as assessed by hemispheric weight disparities. However, 1S,3R-ACPD markedly potentiated N-methyl-D-aspartate (NMDA)-, but not alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA)-, mediated brain injury. This effect was stereoselective since the inactive metabotropic agonist, 1R,3S-ACPD, did not potentiate NMDA toxicity.
引用
收藏
页码:353 / 354
页数:2
相关论文
共 7 条
[1]   SELECTIVE ACTIVATION OF QUISQUALATE METABOTROPIC RECEPTOR POTENTIATES NMDA BUT NOT AMPA RESPONSES [J].
ANIKSZTEJN, L ;
BREGESTOVSKI, P ;
BENARI, Y .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 205 (03) :327-328
[2]  
HARVEY J, 1991, BRIT J PHARMACOL, V104, pC79
[3]   A METABOTROPIC GLUTAMATE RECEPTOR AGONIST DOES NOT MEDIATE NEURONAL DEGENERATION IN CORTICAL CULTURE [J].
KOH, JY ;
PALMER, E ;
LIN, A ;
COTMAN, CW .
BRAIN RESEARCH, 1991, 561 (02) :338-343
[4]   PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL ROLES OF EXCITATORY AMINO-ACIDS DURING CENTRAL-NERVOUS-SYSTEM DEVELOPMENT [J].
MCDONALD, JW ;
JOHNSTON, MV .
BRAIN RESEARCH REVIEWS, 1990, 15 (01) :41-70
[5]   QUANTITATIVE ASSESSMENT OF NEUROPROTECTION AGAINST NMDA-INDUCED BRAIN INJURY [J].
MCDONALD, JW ;
ROESER, NF ;
SILVERSTEIN, FS ;
JOHNSTON, MV .
EXPERIMENTAL NEUROLOGY, 1989, 106 (03) :289-296
[6]   INVITRO AND INVIVO PHARMACOLOGY OF TRANS AND CIS-(+/-)-1-AMINO-1,3-CYCLOPENTANEDICARBOXYLIC ACID - DISSOCIATION OF METABOTROPIC AND IONOTROPIC EXCITATORY AMINO-ACID RECEPTOR EFFECTS [J].
SCHOEPP, DD ;
JOHNSON, BG ;
SALHOFF, CR ;
MCDONALD, JW ;
JOHNSTON, MV .
JOURNAL OF NEUROCHEMISTRY, 1991, 56 (05) :1789-1796
[7]   COMPARISON OF (1S,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID (1S,3R-ACPD)-STIMULATED AND 1R,3S-ACPD-STIMULATED BRAIN PHOSPHOINOSITIDE HYDROLYSIS [J].
SCHOEPP, DD ;
JOHNSON, BG ;
TRUE, RA ;
MONN, JA .
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1991, 207 (04) :351-353