THE INTERLEUKIN-6-DEPENDENT DNA-BINDING PROTEIN GENE (TRANSCRIPTION FACTOR-5 - TCF5) MAPS TO HUMAN CHROMOSOME-20 AND RAT CHROMOSOME-3, THE IL6-RECEPTOR LOCUS (IL6R) TO HUMAN CHROMOSOME-1 AND RAT CHROMOSOME-2, AND THE RAT IL6-GENE TO RAT CHROMOSOME-4

Using two panels of somatic cell hybrids segregating either human or rat chromosomes, the gene encoding the interleukin-6-dependent DNA-binding protein, also called liver activator protein (designated transcription factor 5: TCF5), was assigned to human chromosome 20 and to rat chromosome 3. The TCF5 gene might be identical with the NF-IL6 gene. The locus encoding the IL6 receptor gene (IL6R) was localized to human chromosome 1 and rat chromosome 2. An IL6R-like (IL6RL) locus was also assigned to human chromosome 9. In addition, the rat interleukin-6 (IL6) gene was assigned to rat chromosome 4. These mapping data allow one to extend comparison between the rat, mouse, and human gene maps. © 1991.