CHARACTERIZATION OF CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES FROM RAT MESENTERIC-ARTERY

被引：29

作者：

KOMAS, N ^{[1
]}

LUGNIER, C ^{[1
]}

ANDRIANTSITOHAINA, R ^{[1
]}

STOCLET, JC ^{[1
]}

机构：

[1] UNIV LOUIS PASTEUR, PHARMACOL CELLULAIRE & MOLEC LAB,CNRS,URA 600, BP 24, F-67401 ILLKIRCH GRAFFENSTADEN, FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1991年 / 208卷 / 01期

关键词：

MESENTERIC ARTERY; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE (INHIBITOR); CYCLIC AMP; CYCLIC GMP; (RAT);

D O I：

10.1016/0922-4106(91)90056-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Four cyclic nucleotide phosphodiesterase activities (PDEs) could be resolved from rat mesenteric artery by DEAE-Sephacel chromatography: a calmodulin-activated fraction, a cyclic GMP-inhibited fraction, a cyclic AMP-specific rolipram-sensitive fraction and a cyclic GMP-specific fraction containing PDE I, III, IV and V. Cardiotonic drugs (CI 930 and LY 195115) selectively inhibited PDE III; rolipram and zaprinast selectively inhibited PDE IV and PDE V, respectively. These results show that the rat mesenteric artery contains the same PDEs as previously found in the aorta, and suggest that these PDEs may be implicated in the regulation of arterial contraction.

引用

页码：85 / 87

页数：3

共 10 条

[1]

BEAVO JA, 1988, ADV SEC MESS PHOSPH, V22, P1

[2] PRIMARY SEQUENCE OF CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE ISOZYMES AND THE DESIGN OF SELECTIVE INHIBITORS [J].