TUMOR-NECROSIS-FACTOR-ALPHA IN STOOL AS A MARKER OF INTESTINAL INFLAMMATION

被引:602
作者
BRAEGGER, CP
NICHOLLS, S
MURCH, SH
STEPHENS, S
MACDONALD, TT
机构
[1] ST BARTHOLOMEWS HOSP,DEPT PAEDIAT GASTROENTEROL,LONDON EC1A 7BE,ENGLAND
[2] CELLTECH LTD,SLOUGH,BERKS,ENGLAND
基金
英国惠康基金;
关键词
D O I
10.1016/0140-6736(92)90999-J
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Measurement of disease activity in patients with inflammatory bowel disease is difficult. The best available methods are complex and time consuming, but it may be possible to use tumour necrosis factor alpha (TNF-alpha) concentration in stool as a marker of disease activity. We measured TNF-alpha concentrations in stool samples from normal children, infants with diarrhoea, and children with inflammatory bowel disease in active and inactive phases of the disease. In 10 normal children and 14 children with diarrhoea, median stool TNF-alpha concentrations were 58 and 45 pg/g stool, respectively. Compared with diarrhoeal controls, stool TNF-alpha concentrations were significantly increased in children with active Crohn's disease (n = 13, median 994 pg/g, p < 0.0002) and active ulcerative colitis (n = 4, range 276-5982 pg/g, p < 0.003). In patients with inactive disease, either as a result of surgery or treatment with steroids, the concentration of stool TNF-alpha fell to those of controls. Measurement of stool TNF-alpha concentations may provide a simple way to monitor disease activity in inflammatory bowel disease.
引用
收藏
页码:89 / 91
页数:3
相关论文
共 10 条
  • [1] CHONG SKF, 1984, BRIT MED J, V284, P101
  • [2] DONNELLAN WL, 1966, GASTROENTEROLOGY, V50, P519
  • [3] CIRCULATING HUMAN PERIPHERAL-BLOOD GRANULOCYTES SYNTHESIZE AND SECRETE TUMOR NECROSIS FACTOR-ALPHA
    DUBRAVEC, DB
    SPRIGGS, DR
    MANNICK, JA
    RODRICK, ML
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) : 6758 - 6761
  • [4] ELIAKIM R, 1988, GASTROENTEROLOGY, V95, P1176
  • [5] INVIVO PROFILES OF EICOSANOIDS IN ULCERATIVE-COLITIS, CROHNS COLITIS, AND CLOSTRIDIUM-DIFFICILE COLITIS
    LAURITSEN, K
    LAURSEN, LS
    BUKHAVE, K
    RASKMADSEN, J
    [J]. GASTROENTEROLOGY, 1988, 95 (01) : 11 - 17
  • [6] ROLE OF INTERLEUKIN-1 IN INFLAMMATORY BOWEL-DISEASE - ENHANCED PRODUCTION DURING ACTIVE DISEASE
    LIGUMSKY, M
    SIMON, PL
    KARMELI, F
    RACHMILEWITZ, D
    [J]. GUT, 1990, 31 (06) : 686 - 689
  • [7] MACDONALD TT, 1990, CLIN EXP IMMUNOL, V81, P351
  • [8] SERUM CONCENTRATIONS OF TUMOR-NECROSIS-FACTOR-ALPHA IN CHILDHOOD CHRONIC INFLAMMATORY BOWEL-DISEASE
    MURCH, SH
    LAMKIN, VA
    SAVAGE, MO
    WALKERSMITH, JA
    MACDONALD, TT
    [J]. GUT, 1991, 32 (08) : 913 - 917
  • [9] SAVERYMUTTU SH, 1983, GASTROENTEROLOGY, V85, P1333
  • [10] PROSTANOID SYNTHESIS BY CULTURED INTESTINAL EPITHELIAL AND MONONUCLEAR-CELLS IN INFLAMMATORY BOWEL-DISEASE
    ZIFRONI, A
    TREVES, AJ
    SACHAR, DB
    RACHMILEWITZ, D
    [J]. GUT, 1983, 24 (07) : 659 - 664