SAC review DNA methylation: a form of epigenetic control of gene expression

被引：120

作者：

Lim, Derek H. K. ^{[1
,2
]}

Maher, Eamonn R. ^{[3
,4
]}

机构：

[1] Univ Birmingham, Inst Biomed Res, Dept Med & Mol Genet, Birmingham B15 2TT, W Midlands, England

[2] Birmingham Womens Hosp, West Midlands Reg Genet Serv, Birmingham B15 2TG, W Midlands, England

[3] Univ Birmingham, Dept Med & Mol Genet, Birmingham, W Midlands, England

[4] West Midlands Reg Genet Serv, Birmingham, W Midlands, England

来源：

OBSTETRICIAN & GYNAECOLOGIST | 2010年 / 12卷 / 01期

关键词：

Beckwith-Wiedemann syndrome; cancer; genomic imprinting; Russell-Silver syndrome; tumour suppressor genes;

D O I：

10.1576/toag.12.1.037.27556

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Key content: Epigenetic factors such as DNA methylation play an important role in regulating gene expression. Aberrant DNA methylation is a feature of a number of important human diseases. Epigenetic changes are common in human cancer cells. Learning objectives: To appreciate the role of DNA methylation as a regulator of gene expression. To understand the role of DNA methylation in normal gene function. To illustrate how DNA methylation is implicated in the regulation of genomic imprinting. To draw attention to how altered DNA methylation can result in human diseases such as imprinting disorders and cancer. Ethical issues: What are the implications for assisted reproductive technologies? There are possible difficulties in interpreting the clinical significance of alterations in DNA methylation.

引用

页码：37 / 42

页数：6

共 34 条

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