NATURE OF THE ENDOGENOUS PYROGEN (EP) INDUCED BY INFLUENZA-VIRUSES - LACK OF CORRELATION BETWEEN EP LEVELS AND CONTENT OF THE KNOWN PYROGENIC CYTOKINES, INTERLEUKIN-1, INTERLEUKIN-6 AND TUMOR-NECROSIS-FACTOR

被引：17

作者：

JAKEMAN, KJ

BIRD, CR

THORPE, R

SMITH, H

SWEET, C

机构：

[1] UNIV BIRMINGHAM,SCH BIOL SCI,MICROBIAL GENET & CELL BIOL RES GRP,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

[2] UNIV BIRMINGHAM,SCH MED,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

[3] NATL INST BIOL STAND & CONTROLS,DIV IMMUNOL,LONDON NW3 6RB,ENGLAND

来源：

JOURNAL OF GENERAL VIROLOGY | 1991年 / 72卷

关键词：

D O I：

10.1099/0022-1317-72-3-705

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Fever in influenza results from the release of endogenous pyrogen (EP) following virus-phagocyte interaction and its level correlates with the differing virulence of virus strains. However, the different levels of fever produced in ferrets by intracardial inoculation of EP obtained from the interaction of different virus strains with ferret or human phagocytes did not correlate with the levels of interleukin 1 (IL-1), IL-6 or tumour necrosis factor in the same samples as assayed by conventional in vitro methods. Hence, the EP produced by influenza virus appears to be different to these cytokines.

引用

页码：705 / 709

页数：5

共 35 条

[1] INTERLEUKIN-1, INTERLEUKIN-6 AND TUMOR NECROSIS FACTOR IN INFECTION, INFLAMMATION AND IMMUNITY [J].