TRANSFORMING GROWTH-FACTOR-BETA - ITS EFFECT ON PHENOTYPE REEXPRESSION BY DEDIFFERENTIATED CHONDROCYTES IN THE PRESENCE AND ABSENCE OF OSTEOGENIN

被引：16

作者：

HARRISON, ET

LUYTEN, FP

REDDI, AH

机构：

[1] Cellular Development/Oncology Lab., National Inst. of Dental Research, National Institutes of Health, Bethesda

来源：

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL | 1992年 / 28A卷 / 06期

关键词：

TGF-BETA; OSTEOGENIN; CHONDROCYTE PHENOTYPE REEXPRESSION;

D O I：

10.1007/BF02634049

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The single and combined actions of transforming growth factor (TGF)-beta and osteogenin were evaluated with regard to induction of colony formation and reexpression of the differentiated phenotype by dedifferentiated rabbit articular chondrocytes in soft agarose under serum-free conditions. TGF-beta alone did not promote colony formation and induced accumulation of proteoglycans and type II collagen at significantly lower levels than those induced by osteogenin. Although synergism between these two growth factors occurred with respect to the induction of colony formation, their joint action on reexpression of the differentiated phenotype was additive. Complex interactions between the two growth factors may explain the latter phenomenon.

引用

页码：445 / 448

页数：4

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