PLASMA-CONCENTRATION, URINARY-EXCRETION AND RENAL CLEARANCE OF L-CARNITINE DURING PREGNANCY - A REVERSIBLE SECONDARY L-CARNITINE DEFICIENCY

被引：21

作者：

MARZO, A

CARDACE, G

CORBELLETTA, C

PACE, S

DIDDIO, S

VERROTTI, C

CAVATORTA, E

GRIGNAFFINI, A

机构：

[1] Drug Metabolism and Pharmacokinetic Department, Parma

[2] Clinical Research Division, Cardiovascular Department, Pomezia, Rome, Parma, Sigma-Tau S.p.A.

[3] Clinica Ostetrica e Ginecologica Università di Parma, Parma

来源：

GYNECOLOGICAL ENDOCRINOLOGY | 1994年 / 8卷 / 02期

关键词：

L-CARNITINE; PREGNANCY; PLASMA CONCENTRATION; RENAL CLEARANCE; SECONDARY L-CARNITINE DEFICIENCY;

D O I：

10.3109/09513599409058032

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Plasma concentration, urinary excretion and renal clearance of free, total and esterified L-carnitine were monitored monthly in 14 women during the last 6 months of pregnancy and 1 month after delivery. Plasma concentration and renal clearance measured 1 month after delivery overlapped with normal values for females of comparable age, and were considered the reference values for further comparisons. Plasma concentration of free, total and esterified L-carnitine decreased during pregnancy, reaching values as low as half of those measured 1 month after delivery, whereas urinary excretion and renal clearance, mainly of L-carnitine esters, increased, with renal clearance reaching apeak at the 16th week of pregnancy. Pregnancy thus leads to a reversible secondary deficiency of L-carnitine. The involvement of L-carnitine in the excretion of an excess of acyl-S-coenzyme A groups to prevent a possible systemic acidosis, as well as hormonal changes and a reduction of L-carnitine biosynthesis, could play a significant role in the variations in L-carnitine metabolism encountered in pregnancy. As physiological components of L-carnitine are excreted via a saturable tubular reabsorption, their threshold seems to follow plasma concentration, even when they decrease markedly, as in pregnancy.

引用

页码：115 / 120

页数：6

共 13 条

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