IONIC BASIS FOR INTRINSIC 40 HZ NEURONAL OSCILLATIONS

被引：80

作者：

WANG, XJ

机构：

[1] Department of Mathematics and The James, Harrisonburg

来源：

NEUROREPORT | 1993年 / 5卷 / 03期

关键词：

40 HZ BRAIN RHYTHM; BIOPHYSICAL MODEL; HODGKIN-HUXLEY FORMALISM; PERSISTENT SODIUM CHANNEL; SLOWLY INACTIVATING POTASSIUM CHANNEL; SUBTHRESHOLD OSCILLATION; CLUSTERING OF NA+ SPIKES; MIXED-MODE BURSTING;

D O I：

10.1097/00001756-199312000-00008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE present a biophysical model of a slowly inactivating potassium ion current I-KS based on recent voltage-clamp data from layer V pyramidal neurons in the cat sensorimotor cortex and show that the interplay between a persistent sodium current I-NaP and I-KS is able to produce intrinsic membrane potential oscillations in the 10- to 50-frequency range. A most notable characteristic of such rhythmicity is what may be termed mixed-mode bursting, where clusters of action potentials alternate in time with epochs of small subthreshold oscillations.

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收藏

页码：221 / 224

页数：4

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