CIRCULATING CYTOTOXIC T-LYMPHOCYTE PRECURSORS IN MAEDI-VISNA VIRUS-INFECTED SHEEP

被引：30

作者：

BLACKLAWS, BA ^{[1
]}

BIRD, P ^{[1
]}

ALLEN, D ^{[1
]}

MCCONNELL, I ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT CLIN VET MED,CAMBRIDGE,ENGLAND

来源：

JOURNAL OF GENERAL VIROLOGY | 1994年 / 75卷

基金：

英国惠康基金;

关键词：

D O I：

10.1099/0022-1317-75-7-1589

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Maedi-visna virus (MVV)-specific cytotoxic T lymphocytes (CTL) were detected, after in vitro culture with MW antigen and recombinant human interleukin-2, in the efferent lymph and peripheral blood of sheep chronically infected with MVV. Cytotoxicity was mediated by CD8(+) lymphocytes and was specific for particular strains of MVV. These precursor CTL were detected in the blood between day 23 and day 100 after infection via the skin. In one out of seven persistently infected sheep MVV-specific cytotoxicity was seen in uncultured peripheral blood cells. Again the effector population consisted of CD8(+) lymphocytes. The only other viral infections in which CTL have been detected in peripheral blood mononuclear cells prior to secondary stimulation are those caused by the simian and human immunodeficiency viruses.

引用

页码：1589 / 1596

页数：8

共 45 条

[1]

ANDERSON AA, 1994, IN PRESS CLIN IMMUNO

[2] EARLY EVENTS IN IMMUNE EVASION BY THE LENTIVIRUS MAEDI-VISNA OCCURRING WITHIN INFECTED LYMPHOID-TISSUE [J].