GYPSETIN, A NEW INHIBITOR OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY NANNIZZIA-GYPSEA VAR INCURVATA IFO-9228 .2. STRUCTURE DETERMINATION

被引：20

作者：

NUBER, B

HANSSKE, F

SHINOHARA, C

MIURA, S

HASUMI, K

ENDO, A

机构：

[1] TOKYO NOKO UNIV,DEPT APPL BIOL SCI,FUCHU,TOKYO 183,JAPAN

[2] UNIV HEIDELBERG,INST ANORGAN CHEM,D-69120 HEIDELBERG,GERMANY

[3] BOEHRINGER MANNHEIM GMBH,W-6800 MANNHEIM 31,GERMANY

来源：

JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 02期

关键词：

D O I：

10.7164/antibiotics.47.168

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The elucidation of the structure of gypsetin, a new inhibitor of acyl-CoA: cholesterol acyltransferase, is described in this paper. By spectroscopic and X-ray crystallographic analyses, the structure of gypsetin has been determined to be 8a, 16a-dihydroxy-5a,l3a-bis[1,1-dimethylallyl]-[1]benzazolidine[3''',2''':4'',5'']azolidino[1'',2'':4',5'][1,4]perhydrodiazin[1',2':1,5]azolidino[2,3-b]-[1]benzazolidine-7,15-dione.

引用

页码：168 / 172

页数：5

共 3 条

[1] GYPSETIN, A NEW INHIBITOR OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY NANNIZZIA-GYPSEA VAR INCURVATA IFO-9228 .1. FERMENTATION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITY
SHINOHARA, C
HASUMI, K
TAKEI, Y
ENDO, A
[J]. JOURNAL OF ANTIBIOTICS, 1994, 47 (02) : 163 - 167
[2] Stahl E, 1969, THIN LAYER CHROMATOG, P494
[3] STRUCTURE OF AMAUROMINE, A NEW ALKALOID WITH VASODILATING ACTIVITY PRODUCED BY AMAUROASCUS SP
TAKASE, S
KAWAI, Y
UCHIDA, I
TANAKA, H
AOKI, H
[J]. TETRAHEDRON LETTERS, 1984, 25 (41) : 4673 - 4676

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