SPERABILLINS, NEW ANTIBACTERIAL ANTIBIOTICS WITH POTENT INVIVO ACTIVITY - TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL-ACTIVITY

被引：18

作者：

KATAYAMA, N ^{[1
]}

NOZAKI, Y ^{[1
]}

TSUBOTANI, S ^{[1
]}

KONDO, M ^{[1
]}

HARADA, S ^{[1
]}

ONO, H ^{[1
]}

机构：

[1] TAKEDA CHEM IND LTD,BIOL RES LABS,YODOGAWA KU,OSAKA 532,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 01期

关键词：

D O I：

10.7164/antibiotics.45.10

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A Gram-negative bacterium was found to produce new antibacterial antibiotics, sperabillins A, B, C and D, and the producing bacterium was characterized and identified as Pseudomonas fluorescens YK-437. Sperabillins were isolated by column chromatographies using cation-exchange resins, activated carbon and cation-exchange Sephadex, and preparative reverse-phase HPLC. Sperabillins showed antibacterial activity against Gram-negative and Gram-positive bacteria including antibiotic-resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus. Sperabillin A inhibited DNA, RNA, protein, and cell wall biosynthesis in Escherichia coli. Sperabillins showed good protective effects in experimentally infected mice.

引用

页码：10 / 19

页数：10

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